Flexible Granulocyte Colony-Stimulating Factor Dosing
نویسندگان
چکیده
As has been reported with other chemotherapeutic agents, evidence is emerging to suggest that increased taxol dose intensity is associated with improved therapeutic efficacy. Granulocyte colony-stimulating factor (G-CSF) effectively protects the bone marrow from taxol-induced neutropenia and allows for higher taxol dose administration. This report addresses the optimal use of G-CSF as a supportive agent for dose-intense taxol therapy. Forty-seven patients were evaluated. Each ovarian cancer patient received taxol with G-CSF support, with starting doses of 250 mg/m2 per 21 days and 10 pg/kg/d, respectively. Five patients were treated with the same dose of G-CSF for multiple cycles. Forty-two patients were given "flexible" G-CSF dosing. Instead of reducing taxol dose after a cycle of therapy complicated by febrile neutropenia (F + N + ), the G-CSF dose was increased. Only after a second episode of F + N + was the taxol dose reduced. The initial 5 patients who developed F + N + after taxol(250 mg/m2) and G-CSF (1 0 pg/
منابع مشابه
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